Muscle Plasticity

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The Muscle Plasticity Research Group is concerned with the mechanisms of clinical plasticity in skeletal muscle.

Using animal studies and case-orientated clinical studies we are looking for new approaches to unresolved questions on how muscle function is maintained and re-established in the light of orthopaedic surgery.

Current projects include:

  • Molecular and cellular characterisation of the timescale of changes in the muscles after tendon rupture and repair
  • Studies on the effects of genomic factors on muscle plasticity in the context of rehabilitative interventions
  • Pharmacological intervention to suppress skeletal muscle atrophy and the associated increase in intramuscular fat after tendon tears.

To answer these biological questions, we use state-of-the-art molecular biology techniques, as well as conventional microanatomy and biochemical methods, on biopsy material taken during operations. In particular, we are focussing on the role of adhesive processes in the muscle fibres in regulating mechanical properties of the stress-modulated phenotype of skeletal muscle.